Last edited by Kajilabar
Monday, May 11, 2020 | History

3 edition of Developmental effects of diethylstilbestrol (DES) in pregnancy found in the catalog.

Developmental effects of diethylstilbestrol (DES) in pregnancy

  • 150 Want to read
  • 37 Currently reading

Published by Thieme-Stratton in New York .
Written in English

    Subjects:
  • Diethylstilbestrol -- Toxicology.,
  • Fetus -- Effect of drugs on.,
  • Generative organs -- Cancer.,
  • Generative organs -- Effect of drugs on.

  • Edition Notes

    Includes bibliographical references and index.

    Statementeditors, Arthur L. Herbst, Howard A. Bern.
    ContributionsHerbst, Arthur L., Bern, Howard Alan, 1920-
    Classifications
    LC ClassificationsRA1242.D48 D48 1981
    The Physical Object
    Paginationxii, 203 p. :
    Number of Pages203
    ID Numbers
    Open LibraryOL4123434M
    ISBN 100913258946
    LC Control Number80071011

    The aim of this study was to determine the effects of an environmental estrogenic chemical bisphenol-A (BPA) on prenatal and postnatal development of female mouse reproductive organs. In the prenatal treatment group, BPA or the synthetic estrogen diethylstilbestrol (DES) were given by subcutaneous (s.c.) injections to pregnant mice during Cited by: The Effects of Diethylstilbestrol on Embryonic Development Estrogen plays a key role in the regulation of gene transcription. This is accomplished by its ability to act as a ligand and to bind to specific.

    Diethylstilbestrol (DES, former BAN stilboestrol) is a synthetic nonsteroidal estrogen that was first synthesized in It is also classified as an endocrine exposure to DES occurred through diverse sources, such as dietary ingestion from supplemented cattle feed and medical treatment for certain conditions, including breast and prostate ation half-life: {{{elimination_half-life}}}.   Diethylstilbestrol syndrome (DES syndrome) refers to developmental or health problems caused by exposure to DES before birth (in utero), such as reproductive tract differences, infertility, and an increased risk for certain cancers. DES is a synthetic form of the female hormone estrogen that was prescribed to pregnant women between about and to prevent .

    Long-term effects on the immune system of an early life exposure to diethylstilbestrol. Banbury Report In; Environmental factors in human growth and development (eds V.R. Hunt, M.K. Smith and D. Worth) p. , Cold Spring Harbor : T. Kalland, R. Hofman. As further demonstration of DOHaD effects, exposure to diethylstilbestrol (DES), a well‐known perinatal carcinogen, also provides an example of the profound effects of oestrogenic chemicals on the developing foetus and neonate (for review, see Herbst & Bern, ; NIH, ). The developmental exposed DES animal model to study obesityCited by:


Share this book
You might also like
Culture warrior

Culture warrior

National Library five-year development plan, 1973-1978.

National Library five-year development plan, 1973-1978.

Dynamic optimization

Dynamic optimization

Cornelii Nepotis Vitae excellentium imperatorum

Cornelii Nepotis Vitae excellentium imperatorum

A little bit of war

A little bit of war

Glamorgan County Cricket Club

Glamorgan County Cricket Club

Results Act

Results Act

London docks

London docks

Bareroot nursery production and practices for white spruce

Bareroot nursery production and practices for white spruce

Jean Paul

Jean Paul

[Statuts définitifs du Congrès

[Statuts définitifs du Congrès

Developmental effects of diethylstilbestrol (DES) in pregnancy Download PDF EPUB FB2

The synthetic estrogen diethylstilbestrol (DES) is a potent perinatal endocrine disrupter. In humans and experimental animal models, exposure to DES during critical periods of differentiation permanently alters estrogen target tissues subsequently resulting in structural, functional, and long‐term abnormalities including neoplasia in reproductive tract by: Additional Physical Format: Online version: Developmental effects of diethylstilbestrol (DES) in pregnancy.

New York: Thieme-Stratton, (OCoLC)   Experimental animal studies support the idea of involvement of EDCs in obesity; developmental exposure to numerous chemicals—including diethylstilbestrol, other estrogens (32), and other chemicals, such as tributyl tin (33)—has been associated with obesity or Cited by: DES, a potent synthetic estrogen, is representative of this chemical class and has known developmental effects at pharmacological levels that are identifiable at sexual maturity.

The effects of neonatal DES over a wide dose range of exposure have been used to predict potential adverse effects of weaker environmental estrogens and to Cited by: The Effects of Diethylstilbestrol (DES) before Birth on the Development of Masculine Behavior in Juvenile Female Rhesus Monkeys.

Diethylstilbestrol (DES) is a synthetic form of the female hormone was prescribed to pregnant women between and to prevent miscarriage, premature labor, and related complications of pregnancy ().The use of DES declined after studies in the s showed that it was not effective in preventing these problems.

Properties: Small plates from benzene, mp °. uv max (N NaOH): nm (E 1%1cm ). Almost insol in water. Sol in alcohol, ether, chloroform, fatty oils, dil hydroxides.

Developmental Exposure to Diethylstilbestrol Alters Uterine Gene Expression That May Be Associated With Uterine Neoplasia Later in LifeCited by: Developmental exposure to xenoestrogens at low doses alters femur length and tensile strength in adult mice.

Effect of in utero exposure to diethylstilbestrol on lumbar and femoral bone, articular cartilage, and the intervertebral disc in male and female adult. Diethylstilbestrol, trans-α,β-diethyl-4,4′-stilbendiol (), is proposed to be synthesized in various ing to one of them, desoxyansoine is alkylated by ethyl iodide in the presence of sodium ethoxide, and the resulting ketone () is reacted in a Grignard reaction with ethylmagnesium bromide, which forms the carbinol ().

Abstract. The “developmental origins of health and disease” (DOHaD) is a concept that has emerged over the past 50 years, linking the state of health and risk from disease in later childhood and adult life with the environmental conditions of the early life.

Diethylstilbestrol DES Transgenerational Effects Adverse health effects in DES grandchildren, and transgenerational transmission of diethylstilbestrol effects through epigenetic modifications. CHE Webinar/ video: Exposure to DES During Pregnancy and Multigenerational Neurodevelopmental Deficits. book: Sexual Differentiation of the Brain.

The avian egg as a test system for endocrine disrupters: effects of diethylstilbestrol and ethynylestradiol on sex organ development. Transsexualism: a review of etiology, diagnosis and treatment. Diethylstilbestrol DES and Mental, Psychological Health Studies. In utero exposure to DES results in a variety of harmful effects, including long-term harms.

Mental health issues reported for DES daughters and DES sons include depression, bipolar disorder, behavioural disorders and schizophrenia. Sources studies about DES and mental health, psychological issues, psychiatric disorders and sexual orientation.

The Effects of Diethylstilbestrol on Embryonic Development [1] By: Cooper-Roth, Tristan Keywords: Estrogen [2] Human development [3] Estrogen plays a key role in the regulation [5] of gene transcription. This is accomplished by its ability to act as a ligand and to.

We describe an animal model of developmental exposure to diethylstilbestrol (DES), a potent perinatal endocrine disruptor with estrogenic activity, to study mechanisms involved in programming an organism for by: DES Books DES Book covers and summary.

Developmental effects of diethylstilbestrol (DES) in pregnancy by DES Daughter 6 DES Stories by DES Daughter 24 DES Voices by DES Daughter 22 2 History of the determination of market share for DES by DES Daughter 2 Gendered Medical Views: 5K.

Diethylstilbestrol, a synthetic nonsteroidal estrogen which was previously used clinically to support pregnancy, has been linked to a variety of long-term adverse effects in women who were treated with it during pregnancy and in their offspring. Diethylstilbestrol Story.

adverse effects included genital anomalies and possible risk of infertility. the developmental window for the adjustment of hormone receptors to their target. Newbold R. Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogesn.

Environ Health Perspect. ; (Suppl 7)–7. [PMC free article] [Google Scholar] Newbold RR. Prenatal exposure to diethylstilbestrol (DES) Fertil Steril. ; e55–6. [Google Scholar]Cited by:. Suzuki, A, Sugihara, A, and, Iguchi, T.Developmental effects of diethylstilbestrol and bisphenol-A on reproductive organs in female mice.

Abstract of 2, nd, Annual Meeting of Japan Society of Endocrine Disruptor Research, by: Effects of neonatal diethylstilbestrol exposure on c-fos and c-jun protooncogene expression in the mouse uterus.

Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract. Prenatal Exposure to Synthetic Progestins and Estrogens: Effects on Human Development.

Pulmonary embolism in a transsexual man taking diethylstilbestrol. book: Man and Woman, Boy and Girl – the differentiation and dimorphism of .